MDASI Multiple Myeloma Module
The MD Anderson Symptom Inventory for multiple myeloma (MDASI-MM) is a disease-specific module. Use the MDASI-MM to assess the severity of symptoms experienced by patients with multiple myeloma and the interference with daily living caused by these symptoms.
Along with the core MDASI’s 13 symptom items and 6 interference items, the MDASI-MM also assesses 7 symptoms specific to multiple myeloma.
| Core MDASI Symptom Items | Multiple Myeloma Symptom Items | MDASI Interference Items |
|---|---|---|
| Pain | Bone aches | Relations with other people |
| Fatigue | Muscle weakness | Enjoyment of life |
| Nausea | Sore mouth or throat | Mood |
| Disturbed sleep | Rash | Walking |
| Distress (feeling upset) | Difficulty concentrating | Activity |
| Shortness of breath | Constipation | Work (including housework) |
| Difficulty remembering | Diarrhea | |
| Lack of appetite | ||
| Drowsiness | ||
| Dry mouth | ||
| Sadness | ||
| Vomiting | ||
| Numbness/tingling |
MDASI-MM Features
- Purpose: To assess the severity of multiple myeloma-related symptoms and the impact of these symptoms on daily functioning
- Population: Patients with symptoms caused by multiple myeloma and its treatment
- Assessment areas: Severity of multiple symptoms and the impact of symptoms on daily functioning during the last 24 hours
- Method: Self-report or interview with research staff; paper-and-pencil or electronic data entry
- Time required: Five minutes or less
- Scoring: Please see the MDASI User Guide
- Reliability: Cronbach alpha reliability ranges from 0.85 to 0.91
View the MDASI-MM (click to enlarge)
MDASI-MM Language Translations
Don't see a language you need? Contact us at symptomresearch@mdanderson.org.
* Arabic and Hebrew versions read right to left.
MDASI User's Guide
In response to the for the pharmaceutical industry on the use of patient-reported outcomes measures in medical product development to support labeling claims, we have prepared a MDASI User Guide to document the development and psychometric properties of the MDASI and its modules, including the MDASI-AML/MDS. The User Guide addresses the recommendations in the FDA guidance and establishes the MDASI's adequacy as a measure to support medical product claims.
Request a copy of the MDASI User Guide.
Selected MDASI-MM References
Validation
Jones D, Vichaya EG, Wang XS, et al. J Hematol Oncol 6(1):13, 2013.
Cleeland CS, Mendoza TR, Wang XS, et al. Cancer 89:634-1646, 2000.
Clinical Application
Weisel K, Dimopoulos MA, San-Miguel J, et al. Hemasphere 7(3):e843, 2023.
Koevoets EW, Schagen SB, de Ruiter MB, et al.; PAM study group. Breast Cancer Res 24(1):36, 2022.
Wang XS, Shi Q, Mendoza TR, et al. Support Care Cancer 29(10):6099-6107, 2021.
Kamal M, Wang XS, Shi Q, et al. Support Care Cancer 29(1):467-475, 2021.
Shi Q, Wang XS, Li G, et al. Cancer 121(7):1138-1146, 2015.
Wang XS, Shi Q, Shah ND, et al. Clin Cancer Res 20(5):1366-1374, 2014.
Methodology
Wang T, Lu Q, Tang L. Support Care Cancer 31(7):431, 2023.
Order the MDASI-MM
Use our convenient online form to order the MDASI-MM for use in your clinical research, clinical practice, funded and non-funded academic research, commercial research, or reproduction in educational materials or other publications.
Did You Know?
Electronic data capture offers several benefits:
- Allows symptom monitoring when the patient is away from the hospital
- Is convenient for patients, who can choose web access, personalized patient portals, or smartphones to access questionnaires
- Minimizes missing data, especially in longitudinal studies
- Provides accurate, real-time symptom data at expected time points
- Generates immediate feedback, potentially allowing caregivers to address severe symptoms more effectively
The MDASI-MM is one of the most widely used patient-reported outcomes assessment tools designed specifically for multiple myeloma. The MDASI-MM's items were derived from patient and clinician input plus literature review and tested in two therapeutic modalities (induction chemotherapy and stem cell transplant).
Sheeba K. Thomas, M.D.
Professor, Lymphoma-Myeloma
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